Non-additive QTL mapping of lactation traits in 124,000 cattle reveals novel recessive loci.

ABSTRACT:

Background

Deleterious recessive conditions have been primarily studied in the context of Mendelian diseases. Recently, several deleterious recessive mutations with large effects were discovered via non-additive genome-wide association studies (GWAS) of quantitative growth and developmental traits in cattle, which showed that quantitative traits can be used as proxies of genetic disorders when such traits are indicative of whole-animal health status. We reasoned that lactation traits in cattle might also reflect genetic disorders, given the increased energy demands of lactation and the substantial stresses imposed on the animal. In this study, we screened more than 124,000 cows for recessive effects based on lactation traits.

Results

We discovered five novel quantitative tra

SUBMITTER: Reynolds EGM 

PROVIDER: S-EPMC8785530 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature