Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management.

ABSTRACT:

Background

Despite major advances in the treatment of diabetic nephropathy (DN) in recent years, it remains the most common cause of end-stage renal disease. An early diagnosis and therapy may slow down the DN progression. Numerous potential biomarkers are currently being researched. Circulating levels of the kidney-released exosomes and biological molecules, which reflect the DN pathology including glomerular and tubular dysfunction as well as mesangial expansion and fibrosis, have shown the potential for predicting the occurrence and progression of DN. Moreover, many experimental therapies are currently being investigated, including stem cell therapy and medications targeting inflammatory, oxidant, or pro-fibrotic pathways activated during the DN progression. The therapeutic pote

SUBMITTER: Peng L 

PROVIDER: S-EPMC8785577 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature