Association of prenatal alcohol exposure with offspring DNA methylation in mammals: a systematic review of the evidence.

ABSTRACT:

Background

Prenatal alcohol exposure (PAE) is associated with a range of adverse offspring neurodevelopmental outcomes. Several studies suggest that PAE modifies DNA methylation in offspring cells and tissues, providing evidence for a potential mechanistic link to Fetal Alcohol Spectrum Disorder (FASD). We systematically reviewed existing evidence on the extent to which maternal alcohol use during pregnancy is associated with offspring DNA methylation.

Methods

A systematic literature search was conducted across five online databases according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Web of Science, EMBASE, Google Scholar and CINAHL Databases were searched for articles relating to PAE in placental mammals. Data were ex

SUBMITTER: Bestry M 

PROVIDER: S-EPMC8785586 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature