HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65.

ABSTRACT:

Background

The NF-κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF-κB transcription factors by viral pathogen-associated molecular patterns, such as viral RNA and DNA, is fundamental to anti-viral innate immune defences and pro-inflammatory cytokine production that steers adaptive immune responses. Diverse non-viral stimuli, such as lipopolysaccharide and cytokines, also activate NF-κB and the same anti-pathogen gene networks. Viruses adapted to human cells often encode multiple proteins targeting the NF-κB pathway to mitigate the anti-viral effects of NF-κB-dependent host immunity.

Results

In this study we have demonstrated using a variety of assays, in a number of different cell ty

SUBMITTER: Fink DL 

PROVIDER: S-EPMC8785589 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature