Dataset Information

Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.

ABSTRACT:

Background

Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD.

Method

Adult subjects (N = 2229; 56.2% male) aged 18-69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA-PGC PTSD sites underwent T1-weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel-wise (brainageR) and region-of-interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age - chronological age) controlling for chronological age, sex, and scan site.

Results

BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three-way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages.

Discussion

Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age-related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.

SUBMITTER: Clausen AN

PROVIDER: S-EPMC8785613 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Publications

Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.

Clausen Ashley N AN Fercho Kelene A KA Monsour Molly M Disner Seth S Salminen Lauren L Haswell Courtney C CC Rubright Emily Clarke EC Watts Amanda A AA Buckley M Nicole MN Maron-Katz Adi A Sierk Anika A Manthey Antje A Suarez-Jimenez Benjamin B Olatunji Bunmi O BO Averill Christopher L CL Hofmann David D Veltman Dick J DJ Olson Elizabeth A EA Li Gen G Forster Gina L GL Walter Henrik H Fitzgerald Jacklynn J Théberge Jean J Simons Jeffrey S JS Bomyea Jessica A JA Frijling Jessie L JL Krystal John H JH Baker Justin T JT Phan K Luan KL Ressler Kerry K Han Laura K M LKM Nawijn Laura L Lebois Lauren A M LAM Schmaal Lianne L Densmore Maria M Shenton Martha E ME van Zuiden Mirjam M Stein Murray M Fani Negar N Simons Raluca M RM Neufeld Richard W J RWJ Lanius Ruth R van Rooij Sanne S Koch Saskia B J SBJ Bonomo Serena S Jovanovic Tanja T deRoon-Cassini Terri T Ely Timothy D TD Magnotta Vincent A VA He Xiaofu X Abdallah Chadi G CG Etkin Amit A Schmahl Christian C Larson Christine C Rosso Isabelle M IM Blackford Jennifer Urbano JU Stevens Jennifer S JS Daniels Judith K JK Herzog Julia J Kaufman Milissa L ML Olff Miranda M Davidson Richard J RJ Sponheim Scott R SR Mueller Sven C SC Straube Thomas T Zhu Xi X Neria Yuval Y Baugh Lee A LA Cole James H JH Thompson Paul M PM Morey Rajendra A RA

Brain and behavior 20211214 1

<h4>Background</h4>Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD.<h4>Method</h4>Adult subjects (N = 2229; 56.2% male) aged 18-69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA-PGC PTSD sites underwent T1-weighted brain structural magnetic resonance imaging, and PTSD ...[more]

PMID: 34907666

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Project description:ObjectiveAttention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these disorders using structural brain imaging data from ENIGMA consortium data.MethodsStructural T1-weighted whole-brain MRI data from healthy control subjects (N=5,827) and from patients with ADHD (N=2,271), ASD (N=1,777), and OCD (N=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. The authors examined subcortical volume, cortical thickness, and cortical surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults, using linear mixed-effects models adjusting for age, sex, and site (and intracranial volume for subcortical and surface area measures).ResultsNo shared differences were found among all three disorders, and shared differences between any two disorders did not survive correction for multiple comparisons. Children with ADHD compared with those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller intracranial volume than control subjects and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared with adult control subjects and other clinical groups. No OCD-specific differences were observed across different age groups and surface area differences among all disorders in childhood and adulthood.ConclusionsThe study findings suggest robust but subtle differences across different age groups among ADHD, ASD, and OCD. ADHD-specific intracranial volume and hippocampal differences in children and adolescents, and ASD-specific cortical thickness differences in the frontal cortex in adults, support previous work emphasizing structural brain differences in these disorders.

Dataset Information

Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.

Background

Method

Results

Discussion

Publications

Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.

Similar Datasets

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