Age-related changes in the rhesus macaque eye.

ABSTRACT:

Purpose

To assess age-related changes in the rhesus macaque eye and evaluate them to corresponding human age-related eye disease.

Methods

Data from eye exams and imaging tests including intraocular pressure (IOP), lens thickness, axial length, and retinal optical coherence tomography (OCT) images were evaluated from 142 individuals and statistically analyzed for age-related changes. Quantitative autofluorescence (qAF) was measured as was the presence of macular lesions as related to age.

Results

Ages of the 142 rhesus macaques ranged from 0.7 to 29 years (mean = 16.4 years, stdev = 7.5 years). Anterior segment measurements such as IOP, lens thickness, and axial length were acquired. Advanced retinal imaging in the form of optical coherence tomography and qAF were obta

SUBMITTER: Lin KH 

PROVIDER: S-EPMC8785649 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature