Influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [¹⁸F]-AV-1451 PET data.

ABSTRACT: Tau PET has allowed for critical insights into in vivo patterns of tau accumulation and change in individuals early in the Alzheimer's disease (AD) continuum. A key methodological step in tau PET analyses is the selection of a reference region, but there is not yet consensus on the optimal region especially for longitudinal tau PET analyses. This study examines how reference region selection influences results related to disease stage at baseline and over time. Longitudinal flortaucipir ([18F]-AV1451) PET scans were examined using several common reference regions (e.g., eroded subcortical white matter, inferior cerebellar gray matter) in 62 clinically unimpaired amyloid negative (CU A-) individuals, 73 CU amyloid positive (CU A+) individuals, and 64 amyloid positive individuals with mild c

SUBMITTER: Young CB 

PROVIDER: S-EPMC8785682 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature