Kidney Biomarkers and Major Adverse Kidney Events in Critically Ill Patients.

ABSTRACT:

Background

Several biomarkers of AKI have been examined for their ability to predict AKI before serum creatinine. Few studies have focused on using kidney biomarkers to better predict major adverse kidney events (MAKE), an increasingly used composite outcome in critical care nephrology research.

Methods

Single-center prospective study collecting blood and urine samples from critically ill patients with AKI Kidney Disease Improving Global Outcomes stage 2 or above, and matched controls from a single, tertiary care intensive care unit (ICU). Samples were collected at 24-48 hours after AKI diagnosis (patients) or ICU admission (controls), 5-7 days later, and 4-6 weeks after discharge for patients with AKI. The primary outcome of interest was MAKE at hospital discharge (MAKE-DC)

SUBMITTER: Flannery AH 

PROVIDER: S-EPMC8785730 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature