D-Serine Mediates Cellular Proliferation for Kidney Remodeling.

ABSTRACT:

Background

d-serine, a long-term undetected enantiomer of serine, is a biomarker that reflects kidney function and disease activity. The physiologic functions of d-serine are unclear.

Methods

The dynamics of d-serine were assessed by measuring d-serine in human samples of living kidney donors using two-dimensional high-performance liquid chromatography, and by autoradiographic studies in mice. The effects of d-serine on the kidney were examined by gene expression profiling and metabolic studies using unilateral nephrectomy mice, and genetically modified cells.

Results

Unilateral nephrectomy in human living kidney donors decreases urinary excretion and thus increases the blood level of d-serine. d-serine is quickly and dominantly distributed to the kidney on injection

SUBMITTER: Hesaka A 

PROVIDER: S-EPMC8785787 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature