Obesity, Anion Accumulation, and Anion Gap Metabolic Acidosis: A Cohort Study.

ABSTRACT:

Background

Obesity is associated with low serum bicarbonate, an indicator of metabolic acidosis and a CKD risk factor. To further characterize acid-base disturbance and subclinical metabolic acidosis in this population, we examined prospective associations of body mass index (BMI) with elevated anion gap and whether anion gap values in obesity associate with low bicarbonate.

Methods

Data from adult outpatients (n=94,448) in the Bronx, New York were collected from 2010 to 2018. Mixed effects models and Cox proportional hazards models were used to examine associations of BMI with elevated anion gap and anion gap metabolic acidosis and of baseline anion gap with incident low bicarbonate and anion gap metabolic acidosis. Anion gap was defined using traditional and albumin

SUBMITTER: Lambert DC 

PROVIDER: S-EPMC8785829 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature