Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats.

ABSTRACT:

Background

The antifibrotic effects of recombinant human relaxin (RLX) in the kidney are dependent on an interaction between its cognate receptor (RXFP1) and the angiotensin type 2 receptor (AT₂R) in male models of disease. Whether RLX has therapeutic effects, which are also mediated via AT₂R, in hypertensive adult and aged/reproductively senescent females is unknown. Thus, we determined whether treatment with RLX provides cardiorenal protection via an AT₂R-dependent mechanism in adult and aged female stroke-prone spontaneously hypertensive rats (SHRSPs).

Methods

In 6-month-old (6MO) and 15-month-old ([15MO]; reproductively senescent) female SHRSP, systolic BP (SBP), GFR, and proteinuria were measured before and after 4 weeks of

SUBMITTER: Barsha G 

PROVIDER: S-EPMC8785838 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature