Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis: A Cluster Randomized Trial.

ABSTRACT:

Background

We conducted this study to examine the effect of taking versus holding BP medications before hemodialysis on intradialytic hypotension (IDH).

Methods

In this cluster randomized trial, each dialysis unit was randomly designated as TAKE or HOLD units. Participants within a TAKE unit were instructed to take all BP medications as prescribed, whereas participants within a HOLD unit were instructed to hold medications dosed more than once daily before hemodialysis. The intervention lasted for 4 weeks. We hypothesized that TAKE would be noninferior to HOLD on the primary outcome of asymptomatic IDH, defined as ≥30% of sessions with nadir systolic BP <90 mm Hg and on the following secondary outcomes: uncontrolled hypertension (predialysis systolic BP >160 mm Hg), failure

SUBMITTER: Chang TI 

PROVIDER: S-EPMC8785843 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature