ALOHA: Aggregated local extrema splines for high-throughput dose-response analysis.

ABSTRACT: Computational methods for genomic dose-response integrate dose-response modeling with bioinformatics tools to evaluate changes in molecular and cellular functions related to pathogenic processes. These methods use parametric models to describe each gene's dose-response, but such models may not adequately capture expression changes. Additionally, current approaches do not consider gene co-expression networks. When assessing co-expression networks, one typically does not consider the dose-response relationship, resulting in 'co-regulated' gene sets containing genes having different dose-response patterns. To avoid these limitations, we develop an analysis pipeline called Aggregated Local Extrema Splines for High-throughput Analysis (ALOHA), which computes individual genomic dose-response fun

SUBMITTER: Davidson SE 

PROVIDER: S-EPMC8785973 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature