The Microbiome and p-Inulin in Hemodialysis: A Feasibility Study.

ABSTRACT:

Background

The intestinal microbiome is an appealing target for interventions in ESKD because of its likely contribution to uremic toxicity. Before conducting clinical trials of microbiome-altering treatments, it is necessary to understand the within-person and between-person variability in the composition and function of the gut microbiome in patients with ESKD.

Methods

We conducted a multicenter, nonrandomized, crossover feasibility study of patients on maintenance hemodialysis consisting of three phases: pretreatment (8 weeks); treatment, during which the prebiotic, p-inulin, was administered at a dosage of 8 g twice daily (12 weeks); and post-treatment (8 weeks). Stool samples were collected 1-2 times per week and blood was collected weekly for 28 weeks. The gut microbio

SUBMITTER: Raj DS 

PROVIDER: S-EPMC8786005 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature