Comparative performance of risk prediction models for hepatitis B-related hepatocellular carcinoma in the United States.

ABSTRACT:

Background & aims

Guidelines recommend hepatocellular carcinoma (HCC) surveillance in patients with chronic HBV infection. Several HCC risk prediction models are available to guide surveillance decisions, but their comparative performance remains unclear.

Methods

Using a retrospective cohort of patients with HBV treated with nucleos(t)ide analogues at 130 Veterans Administration facilities between 9/1/2008 and 12/31/2018, we calculated risk scores from 10 HCC risk prediction models (REACH-B, PAGE-B, m-PAGE-B, CU-HCC, HCC-RESCUE, CAMD, APA-B, REAL-B, AASL-HCC, RWS-HCC). We estimated the models' discrimination and calibration. We calculated HCC incidence in risk categories defined by the reported cut-offs for all models.

Results

Of 3,101 patients with HBV (32.2% with ci

SUBMITTER: Kim HS 

PROVIDER: S-EPMC8786210 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature