Elevated customary alcohol consumption attenuates opioid effects.

ABSTRACT:

Background

Regular alcohol consumption is on the rise among older adults and has the potential of altering the subjective experience of pain and response to pain medications. This study examined the cognitive, analgesic and side effect response to oxycodone in middle age and older adults with elevated levels of customary alcohol consumption in a human laboratory setting.

Methods

After refraining from alcohol for one day, eligible participants underwent baseline assessment cognition and side effects by means of questionnaires that were repeated at three time points (90 min, 5 and 8 h) following administration of a 10 mg oral dose of oxycodone. Response to pain stimulus (Cold Pressor Test (CPT)), pupil size, and plasma oxycodone were also measured.

Results

One hundred t

SUBMITTER: Cherrier MM 

PROVIDER: S-EPMC8786266 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature