Psychotic-like Experiences and Polygenic Liability in the Adolescent Brain Cognitive Development Study.

ABSTRACT:

Background

Childhood psychotic-like experiences (PLEs) often precede the development of later severe psychopathology. This study examined whether childhood PLEs are associated with several psychopathology-related polygenic scores (PGSs) and additionally examined possible neural and behavioral mechanisms.

Methods

Adolescent Brain Cognitive Development Study baseline data from children with European ancestry (n = 4650, ages 9-10 years, 46.8% female) were used to estimate associations between PLEs (i.e., both total and presence of significantly distressing) and PGSs for psychopathology (i.e., schizophrenia, psychiatric cross-disorder risk, PLEs) and related phenotypes (i.e., educational attainment [EDU], birth weight, inflammation). We also assessed whether variability in brain

SUBMITTER: Karcher NR 

PROVIDER: S-EPMC8786267 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature