Ontology highlight
ABSTRACT:
SUBMITTER: Lees JA
PROVIDER: S-EPMC8786282 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Lees Joshua A JA Dias Joao M JM Han Seungil S
Biochemical Society transactions 20211201 6
Electron cryo-microscopy (cryo-EM) is a powerful technique for the structural characterization of biological macromolecules, enabling high-resolution analysis of targets once inaccessible to structural interrogation. In recent years, pharmaceutical companies have begun to utilize cryo-EM for structure-based drug design. Structural analysis of integral membrane proteins, which comprise a large proportion of druggable targets and pose particular challenges for X-ray crystallography, by cryo-EM has ...[more]