Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension.

ABSTRACT: Dietary restriction (DR) has been shown to increase lifespan in organisms ranging from yeast to mammals. This suggests that the underlying mechanisms may be evolutionarily conserved. Indeed, upstream signalling pathways, such as TOR, are strongly linked to DR-induced longevity in various organisms. However, the downstream effector proteins that ultimately mediate lifespan extension are less clear. To shed light on this, we used a proteomic approach on budding yeast. Our reasoning was that analysis of proteome-wide changes in response to DR might enable the identification of proteins that mediate its physiological effects, including replicative lifespan extension. Of over 2500 proteins we identified by liquid chromatography-mass spectrometry, 183 were significantly altered in expression by

SUBMITTER: Campion R 

PROVIDER: S-EPMC8786290 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature