Ontology highlight
ABSTRACT:
SUBMITTER: Quixabeira DCA
PROVIDER: S-EPMC8786329 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Quixabeira Dafne C A DCA Cervera-Carrascon Victor V Santos Joao M JM Clubb James H A JHA Kudling Tatiana V TV Basnet Saru S Heiniö Camilla C Grönberg-Vähä-Koskela Susanna S Anttila Marjukka M Havunen Riikka R Kanerva Anna A Hemminki Akseli A
Oncoimmunology 20220122 1
Intratumoral immunotherapies are entering clinical use but concerns remain regarding their effects on non-injected tumors. Here, we studied the impact of local treatment with an adenovirus coding for TNFa and IL-2 on systemic antitumor response in animals receiving aPD-1 (anti-programmed cell death protein 1) therapy. Using bilateral murine melanoma models, we tested systemic tumor response to combined therapy with anti-PD-1 and an adenovirus coding for TNFa and IL-2 ("virus"). Virus was given i ...[more]