Diet-Derived Circulating Antioxidants and Risk of Stroke: A Mendelian Randomization Study.

ABSTRACT:

Background

Oxidative stress is crucial in stroke pathogenesis. Many cohort-based studies suggested that the intake of exogenous antioxidants originated from food may prevent stroke. However, the corresponding randomized controlled trials did not show diet-derived antioxidants have a protective effect on stroke.

Objectives

To examine the association of genetically proxied diet-derived antioxidants with stroke risk using Mendelian randomization.

Methods

We performed a two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of diet-derived antioxidants on stroke risk. For exposure data, we extracted genetic variants as instrumental variables (IVs) that are strongly associated with frequently used diet-derived antioxidants, including vitamin C, vita

SUBMITTER: Miao R 

PROVIDER: S-EPMC8786473 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature