Clinical outcomes in individuals at clinical high risk of psychosis who do not transition to psychosis: a meta-analysis.

ABSTRACT:

Aims

The clinical outcomes of individuals at clinical high risk of psychosis (CHR-P) who do not transition to psychosis are heterogeneous and inconsistently reported. We aimed to comprehensively evaluate longitudinally a wide range of outcomes in CHR-P individuals not developing psychosis.

Methods

"Preferred Reporting Items for Systematic reviews and Meta-Analyses" and "Meta-analysis Of Observational Studies in Epidemiology"-compliant meta-analysis (PROSPERO: CRD42021229212) searching original CHR-P longitudinal studies in PubMed and Web of Science databases up to 01/11/2021. As primary analysis, we evaluated the following outcomes within CHR-P non-transitioning individuals: (a) change in the severity of attenuated psychotic symptoms (Hedge's g); (b) change in the severity o

SUBMITTER: Salazar de Pablo G 

PROVIDER: S-EPMC8786617 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature