Vaccine strain affects seroconversion after influenza vaccination in COPD patients and healthy older people.

ABSTRACT: Though clinical guidelines recommend influenza vaccination for chronic obstructive pulmonary disease (COPD) patients and other high-risk populations, it is unclear whether current vaccination strategies induce optimal antibody responses. This study aimed to identify key variables associated with strain-specific antibody responses in COPD patients and healthy older people. 76 COPD and 72 healthy participants were recruited from two Australian centres and inoculated with influenza vaccine. Serum strain-specific antibody titres were measured pre- and post-inoculation. Seroconversion rate was the primary endpoint. Antibody responses varied between vaccine strains. The highest rates of seroconversion were seen with novel strains (36-55%), with lesser responses to strains included in the vaccine

SUBMITTER: Snape N 

PROVIDER: S-EPMC8786852 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature