Prognostic implications of N⁶-methyladenosine RNA regulators in breast cancer.

ABSTRACT: The significance of N⁶-methyladenosine (m6A) RNA modifications in the progression of breast cancer (BC) has been recognised. However, their potential role and mechanism of action in the tumour microenvironment (TME) and immune response has not been demonstrated. Thus, the role of m6A regulators and their downstream target gene components in BC remain to be explored. In this study, we used a series of bioinformatics methods and experiments to conduct exploratory research on the possible role of m6A regulators in BC. First, two regulatory modes of immune activation and inactivation were determined by tumour classification. The TME, immune cell infiltration, and gene set variation analysis results confirmed the reliability of this pattern. The prognostic model of the m6A regulator

SUBMITTER: Tai J 

PROVIDER: S-EPMC8786853 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature