Muscle-derived fibro-adipogenic progenitor cells for production of cultured bovine adipose tissue.

ABSTRACT: Cultured meat is an emergent technology with the potential for significant environmental and animal welfare benefits. Accurate mimicry of traditional meat requires fat tissue; a key contributor to both the flavour and texture of meat. Here, we show that fibro-adipogenic progenitor cells (FAPs) are present in bovine muscle, and are transcriptionally and immunophenotypically distinct from satellite cells. These two cell types can be purified from a single muscle sample using a simple fluorescence-activated cell sorting (FACS) strategy. FAPs demonstrate high levels of adipogenic potential, as measured by gene expression changes and lipid accumulation, and can be proliferated for a large number of population doublings, demonstrating their suitability for a scalable cultured meat production pro

SUBMITTER: Dohmen RGJ 

PROVIDER: S-EPMC8786866 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature