Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals.

ABSTRACT: Depression is strongly associated with obesity among other chronic physical diseases. The latest mega- and meta-analysis of genome-wide association studies have identified multiple risk loci robustly associated with depression. In this study, we aimed to investigate whether a genetic-risk score (GRS) combining multiple depression risk single nucleotide polymorphisms (SNPs) might have utility in the prediction of this disorder in individuals with obesity. A total of 30 depression-associated SNPs were included in a GRS to predict the risk of depression in a large case-control sample from the Spanish PredictD-CCRT study, a national multicentre, randomized controlled trial, which included 104 cases of depression and 1546 controls. An unweighted GRS was calculated as a summation of the number o

SUBMITTER: Anguita-Ruiz A 

PROVIDER: S-EPMC8786870 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature