Validation and test-retest repeatability performance of parametric methods for [¹¹C]UCB-J PET.

ABSTRACT: [¹¹C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [¹¹C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this study was to evaluate the quantitative accuracy and the 28-day test-retest repeatability (TRT) of various parametric quantitative methods for dynamic [¹¹C]UCB-J studies in Alzheimer's disease (AD) patients and healthy controls (HC). Eight HCs and seven AD patients underwent two 60-min dynamic [¹¹C]UCB-J PET scans with arterial sampling over a 28-day interval. Several plasma-input based and reference-region based parametric methods were used to generate parametric images using metabolite corrected plasma activity as input function or white matter semi-ovale

SUBMITTER: Tuncel H 

PROVIDER: S-EPMC8786991 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature