The "Obesity Paradox" in Patients With HFpEF With or Without Comorbid Atrial Fibrillation.

ABSTRACT: Background: Overweight and mildly obese individuals have a lower risk of death than their normal-weight counterparts; this phenomenon is termed "obesity paradox." Whether this "obesity paradox" exists in patients with heart failure (HF) or can be modified by comorbidities is still controversial. Our current study aimed to determine the association of body mass index (BMI) with outcomes with patients with HF with preserved ejection fraction (HFpEF) with or without coexisting atrial fibrillation (AF). Methods: Patients with HFpEF from the Americas in the TOPCAT trial were categorized into the 3 groups: normal weight (18.5-24.9 kg/m²), overweight (25.0-29.9 kg/m²), and obesity (≥30 kg/m²). The Cox proportional-hazards models were used to calculat

SUBMITTER: Guo L 

PROVIDER: S-EPMC8787078 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature