Metabolic and functional impairment of CD8⁺ T cells from the lungs of influenza-infected obese mice.

ABSTRACT: Obesity is an independent risk factor for morbidity and mortality in response to influenza infection. However, the underlying mechanisms by which obesity impairs immunity are unclear. Herein, we investigated the effects of diet-induced obesity on pulmonary CD8⁺ T cell metabolism, cytokine production, and transcriptome as a potential mechanism of impairment during influenza virus infection in mice. Male C57BL/6J lean and obese mice were infected with sub-lethal mouse-adapted A/PR/8/34 influenza virus, generating a pulmonary anti-viral and inflammatory response. Extracellular metabolic flux analyses revealed pulmonary CD8⁺ T cells from obese mice, compared with lean controls, had suppressed oxidative and glycolytic metabolism at day 10 post-infection. Flow cytometry sho

SUBMITTER: Green WD 

PROVIDER: S-EPMC8787296 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature