Prediction of Mechanosensitive Genes in Vascular Endothelial Cells Under High Wall Shear Stress.

ABSTRACT: Objective: The vulnerability of atherosclerotic plaques is among the leading cause of ischemic stroke. High wall shear stress (WSS) promotes the instability of atherosclerotic plaques by directly imparting mechanical stimuli, but the specific mechanisms remain unclear. We speculate that modulation of mechanosensitive genes may play a vital role in accelerating the development of plaques. The purpose of this study was to find mechanosensitive genes in vascular endothelial cells (ECs) through combining microarray data with bioinformatics technology and further explore the underlying dynamics-related mechanisms that cause the progression and destabilization of atherosclerotic plaques. Methods: Microarray data sets for human vascular ECs under high and normal WSS were retrieved f

SUBMITTER: Shen L 

PROVIDER: S-EPMC8787366 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature