Raman Molecular Fingerprints of SARS-CoV-2 British Variant and the Concept of Raman Barcode.

ABSTRACT: The multiple mutations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus have created variants with structural differences in both their spike and nucleocapsid proteins. While the functional relevance of these mutations is under continuous scrutiny, current findings have documented their detrimental impact in terms of affinity with host receptors, antibody resistance, and diagnostic sensitivity. Raman spectra collected on two British variant sub-types found in Japan (QK002 and QHN001) are compared with that of the original Japanese isolate (JPN/TY/WK-521), and found bold vibrational differences. These included: i) fractions of sulfur-containing amino acid rotamers, ii) hydrophobic interactions of tyrosine phenol ring, iii) apparent fractions of RNA purines and pyrim

SUBMITTER: Pezzotti G 

PROVIDER: S-EPMC8787433 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature