Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein.

ABSTRACT: Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression. Porcine endogenous retroviruses (PERVs) are an understudied class of endogenous retroviruses that infect cultured human cells, raising concern regarding porcine xenografts. The PERV envelope glycoprotein has also been proposed as a possible swine syncytin with a role in placental development. Despite the growing interest in PERVs, their envelope glycoproteins remain poorly characterized. Here, we successfully determined the postfusion crystal structure of the PERV core fusion ectodomain. The PERV fusion protein structure reveals a conserved class I viral fusion protein six-helix bundle. Bioph

SUBMITTER: Dean TT 

PROVIDER: S-EPMC8787476 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature