Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses.

ABSTRACT: The majority of drug discovery efforts against herpesviruses have focused on nucleoside analogs that target viral DNA polymerases, agents that are associated with dose-limiting toxicity and/or a narrow spectrum of activity. We are pursuing a strategy based on targeting two-metal ion-dependent (TMID) viral enzymes. This family of enzymes consists of structurally related proteins that share common active sites containing conserved carboxylates predicted to coordinate divalent cations essential for catalysis. Compounds that target TMID enzymes, such as HIV integrase and influenza endoribonuclease, have been successfully developed for clinical use. HIV integrase inhibitors have been reported to inhibit replication of herpes simplex virus (HSV) and other herpesviruses; however, the molecular ta

SUBMITTER: DiScipio KA 

PROVIDER: S-EPMC8787488 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature