Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

ABSTRACT:

Purpose

Observational studies have suggested that individuals with pre-existing sleep apnea (SA) have up to double the risk of developing glaucoma than individuals without SA. Understanding risk factors for glaucoma is important to assist with well-structured screening, early intervention, and efficient allocation of specialist consultation. The objective of this study is therefore to use genetic data to determine whether SA is a causal risk factor for glaucoma.

Methods

Two-sample Mendelian randomization (MR) analyses were performed to assess the association between genetically predicted SA and glaucoma susceptibility using genome-wide association study (GWAS) of 25,062 SA cases, 313,372 controls derived from 23andMe and summary data from a glaucoma GWAS meta-analysis (20,58

SUBMITTER: Ingold N 

PROVIDER: S-EPMC8787584 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature