Multiple Sclerosis Disease Activity and Disability Following Discontinuation of Natalizumab for Pregnancy.

ABSTRACT:

Importance

The magnitude of risk of pregnancy-related multiple sclerosis relapses, particularly severe relapses, following natalizumab cessation is unclear, as is whether this risk is reduced by pregnancy or other modifiable factors.

Objective

To determine the association of early natalizumab withdrawal before or during pregnancy with risk of severe relapses and relapse-related disability.

Design, setting, and participants

This prospective cohort study used data from the German Multiple Sclerosis and Pregnancy Registry, which enrolled participants between November 2006 and February 2018. Data were collected through structured telephone-administered questionnaires and review of neurologists' notes. Registry patients who stopped natalizumab treatment within the 2 years

SUBMITTER: Hellwig K 

PROVIDER: S-EPMC8787598 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature