Potential-Driven Electrochemical Clearing of Ex Vivo Alkaline Corneal Injuries.

ABSTRACT:

Purpose

Corneal chemical injuries (CCI) obscure vision by opacifying the cornea; however, current treatments may not fully restore clarity. Here, we investigated potential-driven electrochemical treatment (P-ECT) to restore clarity after alkaline-based CCI in ex vivo rabbit corneas and examined collagen fiber orientation changes using second harmonic generation (SHG).

Methods

NaOH was applied to the corneas of intact New Zealand white rabbit globes. P-ECT was performed on the opacified cornea while optical coherence tomography (OCT) imaging (∼35 frames per second) was simultaneously performed. SHG imaging evaluated collagen fiber structure before NaOH application and after P-ECT. Irrigation with water served as a control.

Results

P-ECT restored local optical clarity a

SUBMITTER: Dilley KK 

PROVIDER: S-EPMC8787648 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature