Tryptophan catabolism is dysregulated in leiomyomas.

ABSTRACT:

Objective

To determine the expression and functional roles of indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) in leiomyoma.

Design

Experimental study.

Setting

Academic research laboratory.

Patient(s)

Women undergoing hysterectomy for leiomyoma.

Intervention(s)

Blockade of IDO1 and TDO2.

Main outcome measure(s)

Expression of IDO1 and TDO2 in leiomyoma and the effects of their inhibitors on the extracellular matrix.

Result(s)

Leiomyoma expressed significantly higher levels of IDO1 and TDO2 messenger ribonucleic acid (mRNA; 60.3%, 35/58 pairs and 98.3%, 57/58 pairs, respectively) and protein (54%, 27/50 pairs and 92%, 46/50 pairs, respectively) as well as the enzyme activity marker kynurenine (78.3%, 36/46 pairs for

SUBMITTER: Chuang TD 

PROVIDER: S-EPMC8787760 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature