High-dose steroids in high pain responders undergoing total knee arthroplasty: a randomised double-blind trial.

ABSTRACT:

Background

Total knee arthroplasty (TKA) is associated with moderate-to-severe postoperative pain despite multimodal opioid-sparing analgesia. Pain catastrophising or preoperative opioid therapy is associated with increased postoperative pain. Preoperative glucocorticoid improves pain after TKA, but dose-finding studies and benefit in high pain responders are lacking.

Methods

A randomised double-blind controlled trial with preoperative high-dose intravenous dexamethasone 1 mg kg^-1 or intermediate-dose dexamethasone 0.3 mg kg^-1 in 88 patients undergoing TKA with preoperative pain catastrophising score >20 or regular opioid use was designed. The primary outcome was the proportion of patients experiencing moderate-to-severe pain (VAS >30) during a 5 m walk

SUBMITTER: Nielsen NI 

PROVIDER: S-EPMC8787770 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature