The potential for autonomic neuromodulation to reduce perioperative complications and pain: a systematic review and meta-analysis.

ABSTRACT:

Background

Autonomic dysfunction promotes organ injury after major surgery through numerous pathological mechanisms. Vagal withdrawal is a key feature of autonomic dysfunction, and it may increase the severity of pain. We systematically evaluated studies that examined whether vagal neuromodulation can reduce perioperative complications and pain.

Methods

Two independent reviewers searched PubMed, EMBASE, and the Cochrane Register of Controlled Clinical Trials for studies of vagal neuromodulation in humans. Risk of bias was assessed; I² index quantified heterogeneity. Primary outcomes were organ dysfunction (assessed by measures of cognition, cardiovascular function, and inflammation) and pain. Secondary outcomes were autonomic measures. Standardised mean difference

SUBMITTER: Patel ABU 

PROVIDER: S-EPMC8787777 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature