Employing Constant Rate Filtration To Assess Active Pharmaceutical Ingredient Washing Efficiency.

ABSTRACT: Washing is a key step in pharmaceutical isolation to remove unwanted crystallization solvents and dissolved impurities (mother liquor) from the active pharmaceutical ingredient (API) filter cake to ensure the purity of the product whilst maximizing yield. It is therefore essential to avoid both product dissolution and impurity precipitation during washing, especially precipitation of impurities caused by the wash solvent acting as an antisolvent, affecting purity and causing agglomerate formation. This work investigates the wash solvent flow through a saturated filter cake to optimize washing by displacement, taking account of diffusional mechanisms and manipulating the wash contact time. Constant rate filtration/washing is employed in this study using readily available laboratory equipmen

SUBMITTER: Shahid M 

PROVIDER: S-EPMC8787817 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature