Importance of circulating adipocytokines in multiple myeloma: a systematic review and meta-analysis based on case-control studies.

ABSTRACT:

Background

Adipocytes and their products, adipocytokines, play important roles in the generation and development of multiple myeloma (MM). Studies have demonstrated some adipocytokines to be associated with MM, although those results are controversial. Therefore, we conducted a meta-analysis to verify the association of adipocytokines with MM.

Methods

We performed a systematic retrieval of literature published prior to 26 October 2021. Standardized mean difference (SMD) with a 95% confidence interval (CI) was calculated to evaluate pooled effects. Subgroup analysis and meta-regression analysis were conducted to detect sources of heterogeneity. Sensitivity analysis was performed to evaluate the stability of the study. Publication bias was assessed by funnel plots and Egger's

SUBMITTER: Liu R 

PROVIDER: S-EPMC8787905 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature