Leaf extract of Osbeckia octandra induces apoptosis in oral squamous cell carcinoma cells.

ABSTRACT:

Background

Osbeckia octandra is a plant endemic to Sri Lanka and is used in ethnomedicine for treating various diseases. However, the anti-cancer properties of O. octandra are yet to be fully investigated. In the present study, we evaluated the anti-cancer effects of O. octandra on oral cancer cells.

Methods

Human oral cancer cell lines (HSC2, YD10B, YD38, YD9, and YD32) were used in this study. BrdU incorporation, cell cycle and annexin-V/PI staining were all evaluated using flow cytometry to determine the extent to which O. octandra leaf extract inhibits cell proliferation and induces apoptosis. Cell viability and reactive oxygen species (ROS) were also measured in order to investigate the anti-cancer effects of O. octandra extracts. Western blotting was performed to detec

SUBMITTER: Kim JY 

PROVIDER: S-EPMC8787916 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature