Microbiota of the prostate tumor environment investigated by whole-transcriptome profiling.

ABSTRACT:

Background

With over 350,000 estimated deaths worldwide in 2018, prostate cancer (PCa) continues to be a major health concern and a significant cause of cancer-associated mortality among men. While cancer in general is considered a disease of the human genome, there is a growing body of evidence suggesting that changes to the healthy microbiota could play a vital role in cancer development, progression, and/or treatment outcome.

Methods

Using a metatranscriptomic approach, we annotated the microbial reads obtained from total RNA sequencing of 106 prostate tissue samples from 94 PCa patients (discovery cohort). We investigated microbial dysbiosis associated with PCa by systematically comparing the microbiomes between benign and malignant tissue samples, between less vs. more-

SUBMITTER: Salachan PV 

PROVIDER: S-EPMC8787950 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature