Variability in newborn telomere length is explained by inheritance and intrauterine environment.

ABSTRACT:

Background

Telomere length (TL) and its attrition are important indicators of physiological stress and biological aging and hence may vary among individuals of the same age. This variation is apparent even in newborns, suggesting potential effects of parental factors and the intrauterine environment on TL of the growing fetus.

Methods

Average relative TLs of newborns (cord tissue, N = 950) and mothers (buffy coat collected at 26-28 weeks of gestation, N = 892) were measured in a birth cohort. This study provides a comprehensive analysis of the effects of heritable factors, socioeconomic status, and in utero exposures linked with maternal nutrition, cardiometabolic health, and mental well-being on the newborn TL. The association between maternal TL and antenatal maternal heal

SUBMITTER: Chen L 

PROVIDER: S-EPMC8787951 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature