Energy-sparing by 2-methyl-2-thiazoline protects heart from ischaemia/reperfusion injury.

ABSTRACT:

Aims

Cardiac ischaemia/reperfusion (I/R) injury remains a critical issue in the therapeutic management of ischaemic heart failure. Although mild hypothermia has a protective effect on cardiac I/R injury, more rapid and safe methods that can obtain similar results to hypothermia therapy are required. 2-Methyl-2-thiazoline (2MT), an innate fear inducer, causes mild hypothermia resulting in resistance to critical hypoxia in cutaneous or cerebral I/R injury. The aim of this study is to demonstrate the protective effect of systemically administered 2MT on cardiac I/R injury and to elucidate the mechanism underlying this effect.

Methods and results

A single subcutaneous injection of 2MT (50 mg/kg) was given prior to reperfusion of the I/R injured 10 week-old male mouse heart and i

SUBMITTER: Nishi M 

PROVIDER: S-EPMC8787978 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature