Degenerative changes of the aortic valve during left ventricular assist device support.

ABSTRACT:

Aims

Donor heart shortage leads to increasing use of left ventricular assist device (LVAD) as bridge-to-transplant or destination therapy. Prolonged LVAD support is associated with aortic valve insufficiency, representing a relevant clinical problem in LVAD patients. Nevertheless, the impact of LVAD support on inflammation, remodelling, and chondro-osteogenic differentiation of the aortic valve is still not clearly understood. The aim of the study is to evaluate the impact of LVAD support on structural and molecular alterations of the aortic valve.

Methods and results

During heart transplantation, aortic valves of 63 heart failure patients without (n = 22) and with LVAD support (n = 41) were collected and used for analysis. Data on clinical course as well as echocardiographi

SUBMITTER: Barth M 

PROVIDER: S-EPMC8788006 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature