Non-targeted metabolomics identify polyamine metabolite acisoga as novel biomarker for reduced left ventricular function.

ABSTRACT:

Aims

Chronic heart failure with reduced ejection fraction remains a major health issue. To date, no reliable biomarker is available to predict reduced left ventricular ejection fraction (LV-EF). We aimed to identify novel circulating biomarkers for reduced left ventricular function using untargeted serum metabolomics in two independent patient cohorts.

Methods and results

Echocardiography and non-targeted serum metabolomics were conducted in two patient cohorts with varying left ventricular function: (1) 25 patients with type 2 diabetes with established cardiovascular disease or high cardiovascular risk (LV-EF range 20-66%) (discovery cohort) and (2) 37 patients hospitalized for myocardial infarction (LV-EF range 25-60%) (validation cohort). In the discovery cohort, untarget

SUBMITTER: Puetz A 

PROVIDER: S-EPMC8788009 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature