Right ventricular function and its coupling to pulmonary circulation predicts exercise tolerance in systolic heart failure.

ABSTRACT:

Aims

Right ventricular (RV) dysfunction, pulmonary hypertension, and exercise intolerance have prognostic values, but their interrelation is not fully understood. We investigated how RV function alone and its coupling with pulmonary circulation (RV-PA) predict cardio-respiratory fitness in patients with heart failure and reduced ejection fraction (HFrEF).

Methods and results

The Evaluation of Resynchronization Therapy for Heart Failure (EARTH) study included 205 HFrEF patients with narrow (n = 85) and prolonged (n = 120) QRS duration undergoing implantable cardioverter defibrillator implantation. All patients underwent a comprehensive evaluation with exercise tolerance tests and echocardiography. We investigated the correlations at baseline between RV parameters {size, funct

SUBMITTER: Legris V 

PROVIDER: S-EPMC8788036 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature