Cytokine storm after heart transplantation in COVID-19-related haemophagocytic lymphohistiocytosis (HLH).

ABSTRACT: While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily causes inflammation in the respiratory system, there is growing evidence of extrapulmonary tissue damage mediated by the host innate immune system in children and adults. A cytokine storm can manifest as a viral-induced haemophagocytic lymphohistiocytosis (HLH). Here, we present a previously healthy 8-year-old boy with newly diagnosed cardiac injury and COVID-19-related HLH syndrome with haemophagocytosis in bone marrow biopsy. After remission of inflammation, the patient underwent a heart transplant due to persistent cardiac failure. The histology of the explanted heart showed only a focal subtle subendocardial inflammation. Three days after transplant, he developed progressive acute respiratory distres

SUBMITTER: Mahdavi M 

PROVIDER: S-EPMC8788054 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature