Differential effects of radiation fractionation regimens on glioblastoma.

ABSTRACT:

Background

Radiotherapy (RT) is a mainstay of treatment for patients with glioblastoma (GB). Early clinical trials show that short course hypofractionation showed no survival benefit compared to conventional regimens with or without temozolomide chemotherapy (TMZ) but reduces the number of doses required. Concerns around delayed neurological deficits and reduced cognition from short course hypofractionated RT remain a concern. The aim of this study was to evaluate the effect of increased interfractional time using two different radiation fractionation regimens on GB.

Methods

The radiobiological effect of increasing doses 0-20 Gy x-ray photon RT on Gl261 and CT2A GB cell lines was compared by colony forming assay, DNA damage by alkaline comet assay, oxidative stress, DNA dama

SUBMITTER: McKelvey KJ 

PROVIDER: S-EPMC8788072 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature